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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN12
All Species:
11.82
Human Site:
S588
Identified Species:
26
UniProt:
Q05209
Number Species:
10
Phosphosite Substitution
Charge Score:
0.3
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
Q05209
NP_001124480.1
780
88120
S588
L
V
D
H
D
N
T
S
P
L
F
R
T
P
L
Chimpanzee
Pan troglodytes
XP_519168
792
88529
S600
L
V
D
H
D
N
T
S
P
L
F
R
T
P
L
Rhesus Macaque
Macaca mulatta
XP_001082837
733
82786
P546
H
G
P
E
N
A
I
P
I
P
D
L
S
E
G
Dog
Lupus familis
XP_540396
757
85032
S565
L
A
D
H
H
N
S
S
P
L
F
R
A
P
L
Cat
Felis silvestris
Mouse
Mus musculus
P35831
775
86973
S588
L
T
E
H
H
N
S
S
P
L
L
K
A
P
L
Rat
Rattus norvegicus
NP_476456
766
85965
H579
S
H
D
L
T
E
H
H
N
S
S
P
L
P
R
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001507461
747
83881
S559
S
K
V
L
G
A
H
S
S
T
P
P
P
R
A
Chicken
Gallus gallus
XP_415970
1211
131521
A1009
S
D
K
S
D
H
T
A
V
S
L
R
A
P
L
Frog
Xenopus laevis
NP_001084841
660
74123
E473
I
P
A
S
G
S
L
E
S
V
V
G
L
P
S
Zebra Danio
Brachydanio rerio
NP_956963
570
64484
D383
V
S
S
A
R
H
S
D
T
Y
H
P
K
P
L
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_796904
967
106580
D639
V
H
I
S
P
P
H
D
K
V
K
D
T
T
E
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
94.5
91.4
88
N.A.
82.8
83.5
N.A.
74.6
48.3
58.2
46.7
N.A.
N.A.
N.A.
N.A.
28.9
Protein Similarity:
100
95.4
92.3
91
N.A.
88.3
88.8
N.A.
81.1
53.5
66.9
57.4
N.A.
N.A.
N.A.
N.A.
44
P-Site Identity:
100
100
0
73.3
N.A.
53.3
13.3
N.A.
6.6
33.3
6.6
13.3
N.A.
N.A.
N.A.
N.A.
6.6
P-Site Similarity:
100
100
13.3
80
N.A.
73.3
13.3
N.A.
6.6
46.6
26.6
33.3
N.A.
N.A.
N.A.
N.A.
20
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
10
10
10
0
19
0
10
0
0
0
0
28
0
10
% A
% Cys:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
10
37
0
28
0
0
19
0
0
10
10
0
0
0
% D
% Glu:
0
0
10
10
0
10
0
10
0
0
0
0
0
10
10
% E
% Phe:
0
0
0
0
0
0
0
0
0
0
28
0
0
0
0
% F
% Gly:
0
10
0
0
19
0
0
0
0
0
0
10
0
0
10
% G
% His:
10
19
0
37
19
19
28
10
0
0
10
0
0
0
0
% H
% Ile:
10
0
10
0
0
0
10
0
10
0
0
0
0
0
0
% I
% Lys:
0
10
10
0
0
0
0
0
10
0
10
10
10
0
0
% K
% Leu:
37
0
0
19
0
0
10
0
0
37
19
10
19
0
55
% L
% Met:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% M
% Asn:
0
0
0
0
10
37
0
0
10
0
0
0
0
0
0
% N
% Pro:
0
10
10
0
10
10
0
10
37
10
10
28
10
73
0
% P
% Gln:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% Q
% Arg:
0
0
0
0
10
0
0
0
0
0
0
37
0
10
10
% R
% Ser:
28
10
10
28
0
10
28
46
19
19
10
0
10
0
10
% S
% Thr:
0
10
0
0
10
0
28
0
10
10
0
0
28
10
0
% T
% Val:
19
19
10
0
0
0
0
0
10
19
10
0
0
0
0
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
0
0
0
0
0
0
0
0
0
10
0
0
0
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _